Wednesday, August 31, 2011

NASA: Space station may be evacuated by late Nov.

FILE - This May 23, 2011 file photo released by NASA, shows the International Space Station flying at an altitude of approximately 220 miles, in an image taken by Expedition 27 crew member Paolo Nespoli from the Soyuz TMA-20 following its undocking. Astronauts may need to temporarily abandon the International Space Station this fall if last week's Russian launch accident prevents new crews from flying, a NASA official said Monday. (AP Photo/NASA, Paolo Nespoli)

FILE - This May 23, 2011 file photo released by NASA, shows the International Space Station flying at an altitude of approximately 220 miles, in an image taken by Expedition 27 crew member Paolo Nespoli from the Soyuz TMA-20 following its undocking. Astronauts may need to temporarily abandon the International Space Station this fall if last week's Russian launch accident prevents new crews from flying, a NASA official said Monday. (AP Photo/NASA, Paolo Nespoli)

In this Sat., Aug. 27, 2011 photo provided by NASA and taken from aboard the international space station by astronaut Ron Garan, the sun rises above above the earth in one of the sixteen sunrises astronauts see each day. This sunrise image shows the rising sun as the space station flew along a path between Rio de Janeiro, Brazil and Buenos Aires, Argentina. (AP Photo/NASA)

FILE - This May 23, 2011 photo made by Expedition 27 crew member Paolo Nespoli from the Soyuz TMA-20 following its undocking and released by NASA shows the International Space Station and the docked space shuttle Endeavour, left. Astronauts may need to temporarily abandon the International Space Station this fall if last week's Russian launch accident prevents new crews from flying, a NASA official said Monday, Aug. 29, 2011. If Russia's essential Soyuz rockets remain grounded beyond mid-November, there will be no way to launch any more astronauts before the current residents are supposed to leave, said NASA's space station program manager, Mike Suffredini. A space station supply ship was destroyed last week following liftoff from Kazakhstan. (AP Photo/NASA, Paolo Nespoli)

(AP) ? Astronauts may need to take the unprecedented step of temporarily abandoning the International Space Station if last week's Russian launch accident prevents new crews from flying there this fall.

Until officials figure out what went wrong with Russia's essential Soyuz rockets, there will be no way to launch any more astronauts before the current residents have to leave in mid-November.

The unsettling predicament comes just weeks after NASA's final space shuttle flight.

"We have plenty of options," NASA's space station program manager, Mike Suffredini, assured reporters Monday. "We'll focus on crew safety as we always do."

Abandoning the space station, even for a short period, would be an unpleasant last resort for the world's five space agencies that have spent decades working on the project. Astronauts have been living aboard the space station since 2000, and the goal is to keep it going until 2020.

Suffredini said flight controllers could keep a deserted space station operating indefinitely, as long as all major systems are working properly. The risk to the station goes up, however, if no one is on board to fix equipment breakdowns.

Six astronauts from three countries presently are living on the orbiting complex. Three are due to leave next month; the other three are supposed to check out in mid-November.

The Sept. 22 launch of the very next crew ? the first to fly in this post-shuttle era ? already has been delayed indefinitely. Russia's Soyuz spacecraft have been the sole means of getting full-time station residents up and down for two years.

To keep the orbiting outpost with a full staff of six for as long as possible, the one American and two Russians due to return to Earth on Sept. 8 will remain on board at least an extra week.

As for supplies, the space station is well stocked and could go until next summer, Suffredini said. Atlantis dropped off a year's supply of goods just last month on the final space shuttle voyage. The unmanned craft destroyed Wednesday was carrying 3 tons of supplies.

For now, operations are normal in orbit, Suffredini noted, and the additional week on board for half the crew will mean additional science research.

The Soyuz has been extremely reliable over the decades; this was the first failure in 44 Russian supply hauls for the space station. Even with such a good track record, many in and outside NASA were concerned about retiring the space shuttles before a replacement was ready to fly astronauts.

Russian space officials have set up an investigation team and until it comes up with a cause for the accident and a repair plan, the launch and landing schedules remain in question. None of the spacecraft debris has been recovered yet; the wreckage fell into a remote, wooded section of Siberia. The third stage malfunctioned; a sudden loss of pressure apparently was noted between the engine and turbopump.

While a crew may well have survived such an accident because of safety precautions built into the manned version of the rocket, no one wants to take any chances.

One or two unmanned Soyuz launches are on tap for October, one commercial and the other another space station supply run. Those would serve as important test flights before putting humans on board, Suffredini said.

NASA considered vacating the space station before, following the space shuttle Columbia disaster in 2003. Back then, shuttles were still being used to ferry some station residents back and forth. Instead, the station got by with two-man crews for three years because of the significant cutback in supplies.

The space station's population doubled in 2009, to six. It wasn't until the space station was completed this year that science research finally took priority.

Even if the space shuttles still were flying, space station crews still would need Soyuz-launched capsules to serve as lifeboats, Suffredini said. The capsules are certified for no more than 6? months in space, thus the need to regularly rotate crews. Complicating matters is the need to land the capsules during daylight hours in Kazakhstan, resulting in weeks of blackout periods.

NASA wants American private companies to take over crew hauls, but that's three to five years away at best. Until then, Soyuz capsules are the only means of transporting astronauts to the space station.

Japan and Europe have their own cargo ships and rockets, for unmanned use only. Commercial front-runner Space Exploration Technologies Corp., or SpaceX, plans to launch a space station supply ship from Cape Canaveral at the end of November. That would be put on hold if no one is on board to receive the vessel.

Suffredini said he hasn't had time to consider the PR impact of abandoning the space station, especially coming so soon after the end of the 30-year shuttle program.

"Flying safely is much, much more important than anything else I can think about right this instant," he said. "I'm sure we'll have an opportunity to discuss any political implications if we spend a lot of time on the ground. But you know, we'll just have to deal with them because we're going to do what's safest for the crew and for the space station."

___

Online:

NASA: http://www.nasa.gov/mission_pages/station/main/index.html

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-08-29-EU-Russia-Space/id-5648188f05d14f87a6c57a365fb59438

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Will Climate Engineering Ever Go Prime Time?

YThis again leads back to my conclusion that people with a liberal mindset believe that resources are running out, and that they need to force change on other people.

No, you have that backwards. They want to force changes on other people and 'resource scarcity' is just a convenient excuse.

How many times have you seen liberals shouting about some disaster and demanding the adoption of free-market policies to solve it? Creating a problem so you can propose a solution which happens to be what you wanted in the first place has been a standard left-wing tactic since at least the 19th century.

So, for example, first you ban drilling for oil and then you shout about 'peak oil'

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/dK4oOe-dWE8/Will-Climate-Engineering-Ever-Go-Prime-Time

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See all of the ... - Beverly Hills Real Estate-Beverly Hills Homes For

Copy of Bel Air Sign2 204x300 See all of the luxury estates, mansions or homes in the Platinum Triangle areas of Bel Air, Bel Air Place, Bel Air Crest, Stone Canyon, & Holmby Hills in Los Angeles, California 90077?  Take a look at all of the luxury estates, homes for sale and listings from the MLS, Multiple Listing Service.CIMG8037 300x151 See all of the luxury estates, mansions or homes in the Platinum Triangle areas of Bel Air, Bel Air Place, Bel Air Crest, Stone Canyon, & Holmby Hills in Los Angeles, California 90077?  Take a look at all of the luxury estates, homes for sale and listings from the MLS, Multiple Listing Service.Bel Air area map

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Are looking to buy a luxury estate or home in the Platinum Triangle areas of Bel Air, Holmby Hills, Bel Air Crest, Bel Air Place, Stone Canyon areas of Los Angeles, California 90077?

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The Christophe Choo Real Estate Group at Coldwell Banker Previews International is the most comprehensive online source for luxury real estate listings, from estate homes to luxury condominiums, incredible tear down opportunities and investment properties. Based in beautiful Beverly Hills, California 90210, the Christophe Choo Real Estate Group provides exclusive luxury homes for sale on a local, global and international stage. Hence the tagline: ?Locally Known ? Globally Connected?. Search for luxury properties in your area, whether in the ?Platinum Triangle? areas of the Westside of Los Angeles of Beverly Hills, Holmby Hills and Bel Air or in The Sunset Strip, Hollywood Hills, Brentwood, Westwood, the Wilshire Corridor, Century City, Pacific Palisades, Santa Monica, Malibu, Venice, Marina Del Rey, Cheviot Hills, Hancock Park, Los Feliz and the key Westside areas of Los Angeles, the Christophe Choo Real Estate Group can help.

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Showing properties 1 - 20 of 137. See more Bel Air - Holmby Hills community real estate.
(all data current as of 8/29/2011)

  1. 12 beds, 15.0 baths

    Lot size: 4.18 ac

    Year built: 2002

    Days on market: 47

    Walk Score?: 18

  2. 9 beds, 21.0 baths

    Lot size: 1.21 ac

    Year built: 1993

    Parking spots: 10

    Days on market: 924

    Walk Score?: 25

  3. 8 beds, 16.0 baths

    Home size: 20,000 sq ft

    Year built: 2003

    Parking spots: 15

    Days on market: 29

    Walk Score?: 28

  4. 30 beds, 41.0 baths

    Year built: 1985

    Parking spots: 15

    Days on market: 121

    Walk Score?: 25

  5. 4 beds, 6.5 baths

    Home size: 8,500 sq ft

    Lot size: 3.06 ac

    Year built: 1965

    Days on market: 141

    Walk Score?: 22

  6. 8 beds, 11.0 baths

    Home size: 18,316 sq ft

    Lot size: 1.57 ac

    Year built: 2002

    Parking spots: 4

    Days on market: 21

    Walk Score?: 32

  7. 8 beds, 11.0 baths

    Home size: 18,316 sq ft

    Lot size: 1.57 ac

    Year built: 2002

    Parking spots: 4

    Days on market: 48

    Walk Score?: 32

  8. 6 beds, 7 full, 7 part baths

    Home size: 27,816 sq ft

    Lot size: 1.18 ac

    Year built: 1993

    Parking spots: 15

    Days on market: 15

    Walk Score?: 35

  9. 6 beds, 15.0 baths

    Home size: 20,000 sq ft

    Lot size: 1.39 ac

    Year built: 1961

    Days on market: 463

    Walk Score?: 18

  10. 5 beds, 7.5 baths

    Home size: 10,528 sq ft

    Lot size: 1.84 ac

    Year built: 1938

    Days on market: 223

    Walk Score?: 22

  11. 5 beds, 7.5 baths

    Home size: 10,528 sq ft

    Lot size: 1.84 ac

    Year built: 1938

    Days on market: 223

    Walk Score?: 22

  12. 5 beds, 11.0 baths

    Lot size: 1.36 ac

    Year built: 2001

    Parking spots: 3

    Days on market: 33

    Walk Score?: 23

  13. 15 beds, 16.5 baths

    Home size: 25,953 sq ft

    Lot size: 1.68 ac

    Parking spots: 12

    Days on market: 11

    Walk Score?: 26

  14. 5 beds, 10.0 baths

    Home size: 13,089 sq ft

    Lot size: 36,600 sq ft

    Year built: 1998

    Days on market: 99

    Walk Score?: 32

  15. 7 beds, 9.0 baths

    Home size: 9,100 sq ft

    Lot size: 1.49 ac

    Year built: 1932

    Days on market: 113

    Walk Score?: 29

  16. 5 beds, 8.0 baths

    Year built: 1929

    Days on market: 120

    Walk Score?: 35

  17. 5 beds, 6 full, 1 part baths

    Home size: 9,000 sq ft

    Lot size: 2.87 ac

    Year built: 1951

    Parking spots: 8

    Days on market: 225

    Walk Score?: 22

  18. 11 beds, 12.0 baths

    Home size: 22,000 sq ft

    Lot size: 38,402 sq ft

    Year built: 2010

    Days on market: 235

    Walk Score?: 6

  19. 9 beds, 11.0 baths

    Home size: 19,000 sq ft

    Lot size: 1.04 ac

    Year built: 2011

    Days on market: 120

    Walk Score?: 40

  20. 7 beds, 12.0 baths

    Home size: 14,000 sq ft

    Lot size: 36,820 sq ft

    Year built: 2007

    Days on market: 341

    Walk Score?: 23

Listing information deemed reliable but not guaranteed. Read full disclaimer.

Source: http://www.christophechoo.com/luxury-estates-mansions-homes-platinum-triangle-areas-bel-air-bel-air-place-bel-air-crest-stone-canyon-holmby-hills-los-angeles-california-90077-luxury-estates-homes-sale-listings-mls-multiple-list-26/

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Tuesday, August 30, 2011

Local Charlotte NC Appliance Service has Nearly 30 Years ...









Tweet This Aviv Service Today is the most educated Charlotte NC Appliance Repair service in the area. The owner, Ofer Hubara began his appliance repair training in 1987 and has had extensive training on all national brads as well as high-end appliances.

Ofer Hubara leads monthly classes to introduce the latest and greatest appliances on the market to his appliance service technicians. Aviv Appliance Repair technicians maintain their cutting-edge skill by attending the annual convention for the Professional Servicer's Association.

Ofer Hubara has enjoyed building lasting relationships with area residents who often refer their family and friends to him when they have appliance problems. Customers express their appreciation for Aviv Service Today for providing a more positive appliance repair experience:

"Technician showed up on time and had a great attitude. He absolutely resolved the problem in the appropriate time and manner. Yes I would use the service again. It was great in every aspect." C.M. Charlotte, NC 28211

As Director of Operations, Ofer Hubaa's role doesn't end at the technical level of the company. His expertise is vitally important to how the Chrlotte NC Appliance Repair company operates behind the scenes and leads the way for other managers to monitor customer satisfaction, marketing efforts and ways to improve Aviv Service Today.

As the proud husband and father of 6 children, Ofer understands how important appliance performance is so he treats all calls as if they were emergencies, providing same-day appliance service with a 5-year parts warranty.

Aviv Service Today specializes in high-end appliance brands including Sub Zero, Bosch, Thermador, Viking, Dacor, Asko, Fisher & Paykel, Scotsman, Wolf and U-Line. Aviv Service Today services most other makes and models of home appliances as well. Visit http://www.charlottencappliancerepair.com/ to learn more about the company and the services they offer.

Contact: Ofer Hubara Aviv Service Today 817 Grand Provincial Ave Matthews, NC 28105-1833 Tel: 704-375-0303 Email: info@avivservicetoday.com Map: http://maps.google.com/maps/place?q=aviv+service+today+charlotte+nc&hl=en&cid=12442384299322707820 This press release was submitted by Right Now Marketing Group, LLC

Aviv Service Todayappliance service appliance service technicians treat every job as if they were servicing their own appliances. Appliance Repair by Aviv Service Today ensures appliances are operating more efficiently to save energy and perform like new. Visit http://www.avivservicetoday.com to learn more.

Keywords: Business, services ,Appliance repair, appliance service, home appliance repair, home appliance service, major appliance repair

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Monday, August 29, 2011

Business Consulting ? Standard Funds Cover Up Review from ...

August 29th, 2011 ? No Comments ? Uncategorized

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Friendly Recreational Outdoor Sports | Articles Reunion

The world we live in is increasingly filled with responsibility, more stressful, and fast-paced. Because of this, everyone needs some time to decompress and have some refreshment. Our modern technique of life as well tends to be inactive, and the meals we eat are not healthy. Exercise is an important component in invigorating us. For these grounds, sports recreation activities are some of the best recreation we can choose. There are many options for spare-time activity to allow for sports recreation. You may even would like to discover some new recreational sports skills.

Classes to acquire new sports recreation attainments can be found online and in larger cities. You are able to study and participate in team sports through the local Y and other organizations. Team sports recreation activities you could like to embark in softball, basketball, baseball, and once in a while in soccer for younger people. A different team sport you might also love bowling. No matter what your skill level, you?ll be able to find a bowling team to have entertainment.

Individual sports recreation activities you can learn and participate in include golf, tennis, running, aerobic dance, gymnastics, and horseback riding. Don?t overlook bicycling and weight training too. Many of these sports can be learned at the local Y as well. For some of these, you?ll want to have a friend to play against or share the experience with. Many runners, for instance, like to run with a friend. And games like tennis and handball really need cooperation for best results.

If you?d rather, you can learn about sports recreation skills online. You can find courses to teach almost any sport or activity you can think of including underwater hockey, fly-fishing, and para-gliding in the Alps! Of course, unless you can get some hands-on experience you?ll only have the theories of the sport. Still, online courses are a good way to get a taste of different sports and recreational activities you might someday want to try out.

A really fun sports recreation game you might get a chance to play is ping pong. Ping pong, or table tennis as it is sometimes called, is played on a table with rubber coated paddles and extremely lightweight plastic balls. You must hit the ball with your paddle so that it strikes the table and clears the net before your opponent strikes it and bounces it back to you. One way to become more adept at ping pong and increase your chance of winning is to sometimes hit the ball harder than at other times. This keeps your opponent guessing what you will do next.

Sports recreation activities are a significant way to stimulate exercise and relieve stress. They?re also numerous fun. Sports truly are an outside outlet that enables you to make friends and participate in healthy exercise. Whether with friends or alone, everybody needs a favorite recreation to participate in.

Leather craftsman and Author Ethan O. Tanner explains the different types of team sports the checklist for soccer for your cherished outdoor recreation activity.

Source: http://articlesreunion.com/health-fitness/exercise/friendly-recreational-outdoor-sports

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Sunday, August 28, 2011

Degrading proteins to divide cells

Friday, August 26, 2011

From bacteria to humans, all forms of life are based on the capacity of one cell to divide into two or more identical daughter cells. In doing so, cells have to produce a copy of their genetic material (DNA) and separate it into two identical sets, one for each daughter cell. Immediately after duplication and before its segregation, DNA is packed in chromosomes that consist of two identical strands joined at a point along their length, called centromeres. Centromeres ensure accurate separation of the chromosomes between daughter cells by directing the assembly of the molecular scaffolding that helps separate cells. The group of scientists led by the IBMB-CSIC Professor and IRB Barcelona researcher Ferran Azor?n has identified the main instrument that Drosophila cells use to control the levels of the CenH3 protein, a key element for defining the identity and function of the centromere in the fruit fly.

CenH3 is a unique variant of conventional histones ?proteins responsible for DNA packaging? found exclusively in the centromeres of all eukaryotes studied to date. "The presence of CenH3 in chromosome regions other than the centromere is sufficient to cause defects in chromosome separation in Drosophila and in budding yeast", explains Azor?n. In yeast and Drosophila, the controlled degradation of CenH3 is known to be one of the mechanisms that regulate its location in the centromere. How this mechanism works, however, has been a mystery until now. The study, led by Azor?n and published online on August 25 in Current Biology, shows that CenH3 interacts specifically with the protein partner of pair (Ppa), involved in directing proteins toward degradation. "We have demonstrated that degradation of CenH3 is essential for limiting its presence at the centromeres and that this degradation is mediated by the protein Ppa, which targets CenH3 to one of the cell's degradation mechanisms, the proteasome", explains Azor?n. The proteasome is a barrel-shape protein structure that breaks down and disposes of unfunctional or unnecessary proteins in the cell. When a protein has to be degraded it needs to be somehow 'tagged' for degradation so it can be detected efficiently and directed to the proteasome. Ppa is part of a 'degradation labelling complex' that marks proteins such as CenH3 with a molecule called ubiquitin for destruction in the proteasome.

"The split between insects and humans during evolution must have occurred about 5 hundred millions years ago. However, most of the molecular components of the centromere have remained practically unchanged in all eukaryotic organisms: CenH3, for example is found in all eukaryotic centromeres", says Azor?n. In Drosophila and also in humans impairment of chromosome segregation during cell division may contribute to disease and birth defects. Thus, errors in centromere function can lead to chromosome instability and aberrant cell division, both of which are often observed in cancer cells. Given the essential roles of the centromeric CenH3 during cell division and the similarities in centromeric structure and function observed among all eukaryotes, the insights into Drosophila centromere stability provided by Azor?n's group may contribute to our understanding of the genetic basis of cancer.

###

Institute for Research in Biomedicine (IRB Barcelona): http://www.irbbarcelona.org

Thanks to Institute for Research in Biomedicine (IRB Barcelona) for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 46 time(s).

Source: http://www.labspaces.net/112844/Degrading_proteins_to_divide_cells

Dead hiker found in Yellowstone National Park

Yellowstone National Park rangers are investigating whether a man found dead along a trail was killed by a grizzly bear.

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The man was found Friday morning by two hikers on the Mary Mountain Trail in the central section of the park. Authorities announced the death Saturday but did not name the man.

Officials said the hiker was in his 60s and a native of Michigan, but withheld further identification pending family notification.

A release from the park said there were "signs of grizzly bear activity at the scene" but that there was no immediate determination of how the man died. Authorities say he likely died Wednesday or Thursday.

The 21-mile-long trail north of the Old Faithful geyser is closed from March to June because park managers list it as "high-density grizzly bear habitat." A park release said that an aerial search of the area Saturday morning failed to turn up any current bear activity.

Hikers on the trails still open were advised to stay on marked trails, hike in groups of three or more people and to make noise and carry bear pepper spray.

Last month, a 57-year-old California man was attacked and killed by a female bear on the popular Wapiti Lake Trail, several miles away from where the Michigan man was discovered.

The female bear that killed the California man was not killed because officials said the sow was only defending its cubs and had not threatened humans before.

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/44299985/ns/travel-news/

Saturday, August 27, 2011

Here's How To Start A Blog To Market Your Home Business/ Network ...

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Source: http://homebusinessplannews.com/articles/heres-how-to-start-a-blog-to-market-your-home-business-network-marketing-company/

Popular Ways In Which You Can Earn a Living Online | Dedicated Web ...

There is nothing like a fast way to make money online. Even If you have a full time job earning a six figure income every month there was the time when you had to learn?

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Resale Rights: You can owe the rights to any sort of product. It can be a sport related product, health related product or any other niche. Owing the rights means you can sell the product at any price you want. It becomes your own product which you can profit from. That is one of the fastest ways to have something
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Create an ebook: On the internet there are free tools that will help you create
an ebook. You type in the paragraphs in Ms Word documents and then convert the document to an ebook. Very simple.

The best way to write an ebook that will help the readers is to use your own experiences. Telling them about your experiences will make your ebook more realistic. You don?t need to be an author. Selling your ebook on eBay is one of the cheap method to start online business.

RSS: RSS is a great method to get more traffic to your website. It can also replace email marketing. When you place RSS ?Remote Site Syndication? on your website will keep getting new organic content on your website.

The best way is to have your own RSS field that others can use. That way your content displays on other websites and that is where the traffic comes from. Some marketers submit also their RSS fields to RSS directories as well. More traffic more sales.

eBay business: There are some things you need to consider when starting or
expanding your eBay business.

Determine the direction of your eBay business. Note down what type of products you want to sell. Decide whether the eBay business will be based on volume or price. Do you want to sell a lot of items for a low price or higher priced items?
Investigate the eBay marketplace and test out the market.

Affiliate: The first quality you need is the willingness to learn and be
trained from an already successful affiliate. A successful affiliate does one thing at a time and completes them on time. You need to think outside the box cause you have a lot of affiliate competitors.

A successful affiliate needs discipline and optimism. You will always find friends, neighbors and relatives that try to discourage you. Remember what the ultimate goal is and keep striving for it.

Sell Ebook on eBay: Once you create your ebook you can instantly setup an eBay
auction to sell the ebook. eBay is easy to use and they have very low fees. You will quickly learn how to setup an eBay auction with the advantage being that your digital product can be sold unlimited times.

After your first auction you will find repeating it an easy task to do. eBay provides explains exactly how to create an auction.

Even though there is some work to do the profit you can make is huge online. I don?t think it is work anymore cause these are no boring lessons you have to learn like you did in school. Enjoy the journey to success.

If you found this article interesting why dont you visit Leland Polik?s website to get more free articles.

Source: http://www.get-to-the-top.com/internet-and-businesses-online/popular-ways-in-which-you-can-earn-a-living-online/?utm_source=rss&utm_medium=rss&utm_campaign=popular-ways-in-which-you-can-earn-a-living-online

Friday, August 26, 2011

How Ebay Security Code | Elfad On Mobile

Free yourself to do more, while securing your business simply and cost-effectively

Overview

As a result of the economic downturn, hard pressed IT departments must face up to their various pressing security needs with ever tighter budgets. And if those numbers aren?t frightening enough, IT faces other numbers that are equally as stark.

A new infected webpage crops up every 4.5 seconds. 2008 saw malicious email attachment increase five-fold. New spam-related webpages arise every 15 seconds. And, to top it off, 97 percent of business email is spam.

Yes, malware is back.

Once a pest likely to cause high-profile damage but manageable with sensible desktop protection and safe backup policies, malware has become increasing sophisticated, devious and stealthy while growing from a pattern of sporadic spikes to a constant deluge of new and unusual attacks (see the chart at right).

Yet workers need access to email and the internet to carry out their business efficiently. They need to move data around fast on USB sticks and other writeable media and as mobility increases they also need remote access to corporate networks from laptops and smart phones. These requirements all present serious threats of accidental leakage or deliberate siphoning off by malicious cybercriminals.

Legislation and regulation of corporate IT use, including rules on accountability, disclosure and secure data handling, are designed to ensure a safer environment, but compliance adds an extra weight to already strained security teams.

There are as many ways of securing a business as there are security vendors showing off approaches to protecting data, systems and networks. It may be tempting to invest in a multi-layered, multi-provider, multi-product approach, attempt to protect against each separate danger with a specific and targeted solution.

However, that approach comes with unanticipated costs to the implementer, with greatly increased requirements in terms of expertise, training, support, maintenance time and effort. Worst of all, disconnected thinking can also leave unexpected gaps in protection.

IT managers cannot afford to soak up the extra costs in equipment, licensing and manpower imposed by an ill-fitting, disparate array of protection solutions. A streamlined, unified approach may well provide excellent savings as well as greatly improved security.

Malware becomes a more sophisticated and growing threat

Sophos uncovers a new infected webpage every ??4.5 seconds

There were five-times more malicious email ??attachments at the end of 2008 than at the beginning

Sophos discovers one new spam-related ??webpage every 15 seconds

Ninety-seven percent of business email is spam??

The growing demands of security

In the last five years, the traditional image of the virus writer as a lonely geek aiming for fame by infecting as widely as possible, or causing maximum damage, has become a thing of the past.

The modern malware creator is a highly driven, often highly skilled programmer, whose work is commissioned and put to use by organised criminal gangs. The goal of malware is money, not recognition, and stealth is highly prized. The methods and techniques for making malware pay expand and evolve at a rapid pace, with the more general risks of infected systems being absorbed into botnets for use in spam campaigns and DDoS attacks, draining bandwidth and resources, supplemented by the more personal dangers of data theft.

Phishing techniques have evolved along similar lines, from simple and generally easily-spotted requests for online banking passwords to subtler, more insidious methods, sometimes personally crafted to penetrate a specific organization and gain access to systems and data. The web is under constant bombardment from hackers probing for vulnerabilities in software or website coding that will allow them to insert their own malcode or extract information from databases supposed to be kept private. At the same time, the black market in credit card and bank login information is booming.

The worldwide recession has only increased the output and sophistication of the attackers. Decreasing salaries and increasing unemployment in high-tech industries has made a move to the criminal underworld ever more appealing for talented programmers.

Meanwhile, the increasing mobility of workers and their data has led to a string of public failures to maintain data security, with tales of sensitive information contained on USB sticks or laptops being lost in the post, left on public transport or sold on eBay seeming to crop up almost every day. The need for encryption and data protection cannot be overstated?the damage to a business when customers learn their credit card data has been exposed on their website or left on a train is irreversible. With a public increasingly aware of the value of their personal data, and made more than usually money-conscious by the economic downturn, trust and reputation are critical to acquiring and retaining customers, and nothing dents a reputation like a public and embarrassing security leak. Sensitive corporate data also has a high value in the wrong hands, and is becoming an ever more highly prized target for today?s data thieves.

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Governments, themselves not unfamiliar with the embarrassment of data leaks, are increasingly tightening regulations regarding data management, and most businesses will be affected in some way by rules on handling customer information, particularly when it comes to financial details. Compliance with regulations requires securing of all vectors for the introduction of malware and the leakage of information, including all operating systems regardless of the perceived malware risk. Maintaining and proving compliance on diverse systems can add a considerable burden to the workload of IT departments and security administrators, even before any incident has occurred.

When a corporate network has been penetrated by malware, there is even more to do. In the wake of an attack, a company must do several things: pin down and isolate the infection vector, remove the malcode and its activities. Then it must assess the potential impact the infection may have had. And it must do all of this in excruciating detail.

The web is under constant bombardment from hackers probing for vulnerabilities in software

The specific flaw in policy or protection that gave the infection access must be identified and fixed, which in a diverse environment running a range of security software can be no easy task. In the case of data loss, similar investigations must find the loss vector and the associated risk, find out what data may have been exposed and, if encryption is employed, whether encryption remains secure.

Once the failing layer has been spotted, the appropriate people must be contacted to provide support and fix any problems. Many of these tasks will be beyond the skills and resources of all but the biggest and most highly-trained of security teams. Often, it?s best delegated to security providers, but when running a range of solutions for different vectors it is not always easy to know which of the range of providers to hand it off to.

The growing costs of security enforcement

IT managers are presented with a bewildering spectrum of requirements in the security arena. Gateways, servers and desktops must be protected from malware infestation and hacker penetration while maintaining required levels of performance. Mail streams must be filtered to remove time-wasting spam, dangerous attachments and social engineering con tricks, but the flow of business-critical communication must not be impeded. Remote devices must be allowed access to networks, but not if they belong to untrusted users. Users need access to online information and resources, but must be shielded from malicious sites. Corporate and customer information must be encrypted and stored safely, with access easily available to those who need it but with the risk of leakage or exfiltration tightly controlled. All these areas need monitoring and managing, ensuring continuous and universal implementation and operation, as well as the application of updates and patches.

Alongside all these balancing acts is another challenging two-edged sword, weighing the investment in acquiring security solutions against the additional, often unforeseen costs. When selecting a security solution, it is tempting to fixate on two clear, but generally contradictory, criteria: performance and purchase price. Considering only which solution will cover a threat vector most effectively, or which will patch it for the lowest initial outlay, ignores a wide swathe of other, equally vital criteria.

The market for security products grows in parallel with the expansion of cyber threats. New start-ups with bright ideas push forward revolutionary new products, while the incumbent giants of the security world roll out new improved versions of their desktop suites, more modules for their corporate UTMs, more complex catch-all appliances. Specialists pronounce themselves ?best of breed? in every arena; anti-spyware product makers belittle the abilities of traditional anti-virus vendors to cope with a slightly different breed of desktop danger. Firewall makers produce ever more complicated and bewildering sets of options to block, mangle or filter incoming and outgoing connections, while NAC vendors promise absolute exclusion of unwanted or untrusted systems from corporate networks. Data leak prevention firms promise to parse the most complex encryption to ensure data cannot be extracted from a protected network, while encryption firms boast of unbreakable, ?military grade? data protection. From amidst this seething sea of offerings, IT managers must pick the arsenal with which they will keep their companies safe and secure.

Security solutions can get a bad reputation with users, interrupting their workflow, slowing down machines, blocking vital access to information. Slowing down the workforce of course raises running costs, as less gets done in more time. Emails lost in spam filters can mean lost business, and can have even more serious legal consequences. Users need to be trained to interact properly with their security software?to check email quarantines, to allow anti-malware updates on their remote devices, to ensure sensitive data is not stored or transferred without proper encryption, not to try to bypass web protection, and to learn divergent methods for interoperating with diverse protection layers can hit training budgets hard. Security policies and solutions require company-wide user acceptance, with users taking responsibility for their part in the security effort, but persuading people to make do with awkward requirements, navigate ill-fitting product combinations or put up with resource-hogging filters can add an extra burden of pain to IT departments, over and above the loss to the company in worker productivity.

Multiple layers of protection covering the multitude of infection and data loss vectors can also, of course, have a heavy impact on IT teams themselves. Simply sourcing a selection of appropriate products can take up time and money, while training admins to properly install, configure and maintain a wide range of solutions can be hugely expensive. Dealing with different interface designs, updating, patching and reporting systems, maintaining support contracts and keeping track of support handlers, ensuring policies are implemented coherently without unnecessary overlaps or dangerous gaps, each task multiplies in complexity with each additional solution provider in a mixed, multi-layered security approach. With IT budgets frozen or even shrinking as competition for business grows and revenues decline, all this additional time and effort takes an ever heavier toll on dwindling resources, while demands increase and the potential cost of a security incident becomes ever more serious. For enterprises to thrive in difficult times, IT teams need to be dedicating their time to projects and initiatives that will add value to the business ? they cannot afford to waste money and effort fighting security fires with expensive and inefficient techniques.

The simple solution

For a business to achieve optimum performance, it cannot be shackled by complex and awkward security processes, but similarly cannot leave itself exposed to danger. For IT managers to ensure all potential security risks are mitigated, they cannot afford simply to opt for the solution with the lowest purchase price to cover each separate need, yet likewise cannot afford an expensive, inflexible and unwieldy modular approach lacking in joined-up thinking. The security of an organization, the safety of its systems, users and data, must be treated holistically as a single goal. To achieve this goal, a single provider who can cover all security requirements in a simple and unified manner, and can deliver the expertise to get it implemented and set up with minimum burden to the IT department, provides the ideal solution.

The essential areas required for a complete and robust protection policy at the desktop level are anti-malware protection with strong proactive elements, on all platforms, along with firewalling, intrusion prevention, network access control, data leak prevention and comprehensive data encryption, all supported by central management and reporting. To have these all handled from a unified system, and supplemented by gateway-

The security of an organization, the safety of its systems, users and data, must be treated holistically as a single goal.

level mail and web filtering, minimises rollout and administration time and energy, and also, thanks to sharing of resources between functions, reduces performance impact perceived by end users and across networks.

By choosing a single security provider to cover every vector, efficiencies can be made across the board. Acquisition, licensing and support arrangements can be made in a single swoop, freeing up time and budget for strategic requirements. Deployment and monitoring of protection for all environments and platforms, enforcement of policies across sites and networks, and incident reporting from all layers of protection can be managed in a joined up way, allowing compliance with internal and external requirements to be easily measured and proven.

Streamlined and uniform design and implementation provide ease of use and reduce the need for multiple, expensively trained in-house experts in a range of products. Access to training and quality, expert support for all protective layers from a single point of contact minimises costs and avoids expensive organisational and logistical requirements imposed by multiple providers, while expertise in multiple threats and threat vectors provides access to informed handling of potential issues in whatever form they arise without the need to analyse the issue internally, with all the associated costs. Multi-skilled expert teams who can look at the needs of a business holistically can provide proactive protection against new threats, and even entirely new threat vectors, relieving IT departments of the burden of keeping ahead of the latest dangers, as well as the hassle and potentially more serious side-effects of a security breach.

A provider that can fit all these requirements can fulfil the need for a complete and comprehensive security policy, and can guarantee to reduce costs into the bargain.

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Thursday, August 25, 2011

Health and fitness Resolutions for the New Year

Every New Year s eve individuals generate resolutions about getting much healthier. These resolutions ordinarily incorporate things like I want to lose lots of weight or from now on I m only eating healthy foods. It is good to desire to be as healthy as you can be. The fact is that there are very few individuals who don t need to improve their health in some way. At the same time, going overboard with New Year s Resolutions is actually common. Unfortunately most people try to do too much too quickly because they shed all of their motivation by February or March.

As we have just stated, Singapore Plastic Surgeons is something that cannot be dismissed ? or at least should never be ignored. No one really can adequately address all the different situations that could arise with this particular topic. That is really a good deal when you think about it, so just the briefest instant to mention something. We are highly certain about the ability of what we offer, today, to create a difference. As usual, we typically save the very finest for last.

So how can someone get out there and get healthy without attempting to do too much too soon? There really are a number of different techniques in play here. The first claims to go bit by bit and create small goals for yourself. The different way of thinking says that it is a lot better to think in the long term and make strategies for how to get there. If you want to improve your health, the two approaches can help you get there. What s more, once you think big and long term, you can simply break that down into several smaller goals that you can reach consecutively. Here are some examples.

If you re looking to lose 50lbs by 2012 that can be divided into a somewhat more than four pounds per month or one pound per week. One pound a week is all it takes. That s absolutely attainable! Simply cutting the pop out of your diet is enough to help you make it happen. Obviously this doesn t imply that cutting out soda by itself will help you reach your fifty pound weight loss goal, but it can help you gather steam at the start while you learn ways to keep the pounds off as you drop them each week.

If you are concerned about animal rights and would like to go the vegan route, don t try to do this all at once. It will hurt your health to do this and the withdrawals the body will go through will make the transition much harder and you won t be able to remain faithful to your new commitment. Start out by ceasing one particular form of meat. Then, after a week or two, get rid of another form of meat. After you ve quit feeding on all of the major kinds of meat, work on cutting out the dairy products. After you have fixed your dependence on dairy, start working on eliminating all of the animal-based ingredients in the bigger foods you eat (jello, for example, contains gelatin which is made from animal products). When you do this you will give yourself more time to learn what to look for on ingredients labels and what new foods you need to eat to make up for the foods that you miss eating.

There are lots of ways to get healthy over the year. New Year s resolutions are terrific for kick starting your enthusiasm levels. Small goals that get met through the months will allow you to stay motivated past the time of year you usually give up the resolutions.

You have just read a fairly thorough overview on Matthew Wilmer Becki Emshoff, but that is nothing extensive by any means. There are other areas that can be discovered that will enhance the information that is generally available. What we will do is go into much deeper are more subtle points that will give you a greater understanding and more benefit. You will find it to be very useful in so many ways, and some of it is very distinct to your particular needs.

Source: http://www.liberal-bias.com/health-and-fitness-resolutions-for-the-new-year

Wrist Pain ? Causes & Solutions | Health

Wristy Business?Is wrist pain interfering with your yoga practice or Pilates workout or Life?

Wrist Pain: Our hands, by design, were not intended for weight bearing, so it?s no wonder that many of us experience pain or discomfort when assuming those Pilates or yoga positions that require us to do just that -bear body weight on our hands. Discomfort may simply be a result of mild limitations in wrist range of motion, improper alignment of shoulders, arms and hands or reduced core and arm strength. Gentle and gradual stretching and strengthening exercises, along with proper body alignment and weight distribution may reduce your wrist discomfort in weight bearing positions. However, for some of us, even with good strength and proper form wrist pain persists. A close look at the anatomy of the hand reveals why.

Hand Anatomy: The hand is designed more for mobility than stability. It is composed of 27 small bones, muscles and ligaments that allow for a large amount of movement and dexterity, enabling us to perform a multitude of daily activities requiring fine precision and coordination. The two bones of the lower arm, the radius and ulna, meet at the carpal bones of the hand to form the wrist. Unlike the foot the hand does not have a large bone cushioned with a fat pad for bearing weight, but has small bones surrounded by soft tissue, including the nerve and blood supply. The median nerve crosses the wrist through the carpal tunnel. These soft tissues of the wrist, including the ligaments and tendons, are subject to strain when we are weight bearing on a fully extended wrist such as in a push-up position.

The Culprits: As a simplification, the common causes of wrist pain are grouped into 4 categories:

Overuse: too much repetitive movement or joint impact Injury: wrist fractures, strains & sprains Lack of conditioning: weak muscles, poor range of motion, improper form Aging or Disease: arthritic changes in the joints, inflammation, diabetes etc.

Which category does your wrist pain originate from?

Overuse: One common cause of wrist pain is Overuse, clinically known as RSI ? Repetitive Stress (or Strain) Injury. Long periods performing the same movements, such as typing on a computer, playing a musical instrument or doing sun salutations, can lead to RSI. Carpal Tunnel Syndrome (CTS) a leading cause of wrist pain is grouped in the RSI category.

What do you do about RSI?

An important first step in treating an overuse injury is to rest ? stop doing what is causing you pain to allow healing time. The reality, however, is that many of our repetitive movements are related to our livelihood such as data input, graphic design, dental hygiene, massage therapist or fitness instructor, so to stop completely might result in a few bounced checks. If complete rest isn?t an option, two ways to decrease repetitive joint stress are through task and schedule modification.

Suggestion One: Modify Your Activity

Once you?ve identified the specific task(s) that?s aggravating your wrists (or other joints) look at how frequently or for what duration you?re performing this task.

Modify your Schedule: The objective of modifying your schedule is to reduce how often and how long you spend doing the pain inducing task. Urgent deadlines, productivity ratings or financial stress are real factors that contribute to overuse injuries. Many smart industries have implemented job rotation and other programs to reduce RSI in the workplace, thus saving money on workman?s compensation claims and lost productivity. Practical examples for modifying your schedule may include:

1) Part Time Work: a schedule of Monday, Wednesday and Friday will allow a day of rest in between.

2) Plan Ahead: instead of spending 6 hours banging out a report on the computer spread it out over 4 days for 1

Source: http://ubccheer.com/wrist-pain-causes-solutions

Wednesday, August 24, 2011

Better 'photon loops' may be key to computer and physics advances

Monday, August 22, 2011

Surprisingly, transmitting information-rich photons thousands of miles through fiber-optic cable is far easier than reliably sending them just a few nanometers through a computer circuit. However, it may soon be possible to steer these particles of light accurately through microchips because of research* performed at the Joint Quantum Institute of the National Institute of Standards and Technology (NIST) and the University of Maryland, together with Harvard University.

The scientists behind the effort say the work not only may lead to more efficient information processors on our desktops, but also could offer a way to explore a particularly strange effect of the quantum world known as the quantum Hall effect in which electrons can interfere with themselves as they travel in a magnetic field. The corresponding physics is rich enough that its investigation has already resulted in three Nobel Prizes, but many intriguing theoretical predictions about it have yet to be observed.

The advent of optical fibers a few decades ago made it possible for dozens of independent phone conversations to travel long distances along a single glass cable by, essentially, assigning each conversation to a different color-each narrow strand of glass carrying dramatic amounts of information with little interference.

Ironically, while it is easy to send photons far across a town or across the ocean, scientists have a harder time directing them to precise locations across short distances-say, a few hundred nanometers-and this makes it difficult to employ photons as information carriers inside computer chips.

"We run into problems when trying to use photons in microcircuits because of slight defects in the materials chips are made from," says Jacob Taylor, a theoretical physicist at NIST and JQI. "Defects crop up a lot, and they deflect photons in ways that mess up the signal."

These defects are particularly problematic when they occur in photon delay devices, which slow the photons down to store them briefly until the chip needs the information they contain. Delay devices are usually constructed from a single row of tiny resonators, so a defect among them can ruin the information in the photon stream. But the research team perceived that using multiple rows of resonators would build alternate pathways into the delay devices, allowing the photons to find their way around defects easily.

As delay devices are a vital part of computer circuits, the alternate-pathway technique may help overcome obstacles blocking the development of photon-based chips, which are still a dream of computer manufacturers. While that application would be exciting, lead author Mohammad Hafezi says the prospect of investigating the quantum Hall effect with the same technology also has great scientific appeal.

"The photons in these devices exhibit the same type of interference as electrons subjected to the quantum Hall effect," says Hafezi, a research associate at JQI. "We hope these devices will allow us to sidestep some of the problems with observing the physics directly, instead allowing us to explore them by analogy."

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*M. Hafezi, E.A. Demler, M.D. Lukin and J.M. Taylor. Robust optical delay lines with topological protection. Nature Physics, Aug. 21, 2011, DOI: 10.1038/NPHYS2063.

National Institute of Standards and Technology (NIST): http://www.nist.gov

Thanks to National Institute of Standards and Technology (NIST) for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/112660/Better__photon_loops__may_be_key_to_computer_and_physics_advances

New TechStars Network Member Gazelle Lab Launches in Tampa Bay

gazellelabI'm here in St. Petersburg, Florida this morning to learn more about the newest TechStars Network member, Gazelle Lab. This 3-month, mentor-driven program is Tampa Bay's attempt to establish itself as a home to?entrepreneurial innovation and a place where early stage startups are fostered. Today, the Lab?launched its first full round of startups today, after having previously launched a "beta" group of just 3 companies earlier this year. Today's launch includes 6 startups, with a diversity of focus ranging from the fun (a mobile adventure quest game) to the practical (an app that listens to your car to help you save you money). The startups will demo in front of investors later this year.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/siBiB4lcEmM/

Tuesday, August 23, 2011

Mohyeldin joins NBC News as foreign correspondent (AP)

NEW YORK ? Former NBC newsman Ayman Mohyeldin is returning to the network where he started his career a decade ago.

Mohyeldin, who will be based in Cairo and cover the Middle East, rejoins NBC next month, the network announced Monday.

He comes from Al Jazeera English, where he has been a correspondent for five years. There he covered Arab revolutions, Israeli politics and human rights abuses in the Arabian Gulf. Prior to that, he worked for Fox News and CNN.

He began his journalism career in 2001 at NBC News as a desk assistant in the network's Washington bureau.

Mohyeldin was born in Cairo and grew up in Detroit, Amman, Jordan, and Marietta, Ga.

Source: http://us.rd.yahoo.com/dailynews/rss/tv/*http%3A//news.yahoo.com/s/ap/20110822/ap_en_tv/us_tv_nbc_news_mohyeldin

Monday, August 22, 2011

sandy - Remove the Buzzing in your soul Ears | Health, Fitness and ...

Buzzing in your ear is usually a type of Ringing in the ears other points can be complaining, whizzing or perhaps phoning. Cute Girl Backpacks Ringing in the ears is usually referred to as a condition, while this is a manifestation of a condition and still medical professionals don?t bodily realize it. Inside lots of cases it can be some type of large pitched noises and some cases a low pitched one. Running out of energy listen to exactly the one sculpt of noises however some may listen to several different tones of noises.It can also may actually filter other seems. Cute Girl Backpacks

It can appear To come from with your brain, other people may declare it seems ahead externally your brain. Consequently what is happening? Even though medical professionals don?t really fully understand that, they certainly realize problems for the ear is part of it. Experience quite loud noises such as good ole? concerts or perhaps perform surroundings, above very long stretches may harm the ears. So what one thing medical professionals don?t fully understand?Some sort of unknown activity in your neurological technique that can cause the noises, Ringing in the ears. Consequently harmed ears on it?s own will not cause ears ringing, it is the activity in your neurological technique, this because been recently found to be linked to your lifetime fashion. Cute Girl Backpacks Little modifications similar to eating habits, could be on your table a thing that units it off. could be you could do this a cheque to ascertain if anything will be setting it off. Merely modest changes in your lifetime fashion may need to be generated to improve and even do away with your own ears ringing for good.

You will find organic approaches to defeat your own ears ringing. Disscover people organic ears ringing therapies today.

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Source: http://carebeautytips.com/articles/remove-the-buzzing-in-your-soul-ears/

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Source: http://tigoytu.livejournal.com/44500.html

Major ALS breakthrough

Major ALS breakthrough [ Back to EurekAlert! ] Public release date: 21-Aug-2011
[ | E-mail | Share Share ]

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University

Researchers discover common cause of all forms of ALS

CHICAGO --- The underlying disease process of amyotrophic lateral sclerosis (ALS and Lou Gehrig's disease), a fatal neurodegenerative disease that paralyzes its victims, has long eluded scientists and prevented development of effective therapies. Scientists weren't even sure all its forms actually converged into a common disease process.

But a new Northwestern Medicine study for the first time has identified a common cause of all forms of ALS.

The basis of the disorder is a broken down protein recycling system in the neurons of the spinal cord and the brain. Optimal functioning of the neurons relies on efficient recycling of the protein building blocks in the cells. In ALS, that recycling system is broken. The cell can't repair or maintain itself and becomes severely damaged.

The discovery by Northwestern University Feinberg School of Medicine researchers, published in the journal Nature, provides a common target for drug therapy and shows that all types of ALS are, indeed, tributaries, pouring into a common river of cellular incompetence.

"This opens up a whole new field for finding an effective treatment for ALS," said senior author Teepu Siddique, M.D., the Les Turner ALS Foundation/Herbert C. Wenske Professor of the Davee Department of Neurology and Clinical Neurosciences at Northwestern's Feinberg School and a neurologist at Northwestern Memorial Hospital. "We can now test for drugs that would regulate this protein pathway or optimize it, so it functions as it should in a normal state."

The discovery of the breakdown in protein recycling may also have a wider role in other neurodegenerative diseases, specifically the dementias. These include Alzheimer's disease and frontotemporal dementia as well as Parkinson's disease, all of which are characterized by aggregations of proteins, Siddique said. The removal of damaged or misfolded proteins is critical for optimal cell functioning, he noted.

This breakdown occurs in all three forms of ALS: hereditary, which is called familial; ALS that is not hereditary, called sporadic; and ALS that targets the brain, ALS/dementia.

In related research, Feinberg School researchers also discovered a new gene mutation present in familial ALS and ALS/dementia, linking these two forms of the disease.

Siddique has been searching for the causes and underlying mechanism of ALS for more than a quarter century. He said he was initially drawn to it because, "It was one of the most difficult problems in neurology and the most devastating, a disease without any treatment or known cause."

Siddique's efforts first showed in 1989 that molecular genetics techniques were applicable to ALS, then described the first ALS gene locus in 1991, which led to the discovery of SOD1 and engineering of the first genetic animal model for ALS.

ALS affects an estimated 350,000 people worldwide, including children and adults, with about 50 percent of people dying within three years of its onset. In the motor disease, people progressively lose muscle strength until they become paralyzed and can no longer move, speak, swallow and breathe. ALS/dementia targets the frontal and temporal lobes of the brain, affecting patients' judgment, the ability to understand language and to perform basic tasks like planning what to wear or organizing their day.

"These people in the prime of their lives and the peak of their productivity get this devastating illness that kills them," Siddique said. "The people who get ALS/dementia, an even more vicious disease, have a double whammy."

BROKEN DOWN RECYCLING SYSTEM

Feinberg School scientists found the cause of ALS by discovering a protein, ubiquilin2, whose critical job is to recycle damaged or misfolded proteins in motor and cortical neurons and shuttle them off to be reprocessed.

In people with ALS, Feinberg researchers found ubiquilin2 isn't doing its job. As a result, the damaged proteins and ubiquilin2 loiter and accumulate in the motor neurons in the spinal cord and cortical and hippocampal neurons in the brain. The protein accumulations resemble twisted skeins of yarn -- characteristic of ALS -- and cause the degeneration of the neurons.

Researchers found ubiquilin2 in these skein-like accumulations in the spinal cords of ALS cases and in the brains of ALS/dementia cases.

The scientists also discovered mutations in ubiquilin2 in patients with familial ALS and familial ALS/dementia. But the skein-like accumulations were present in people's brains and spinal cords in all forms of ALS and ALS/dementia, whether or not they had the gene mutation.

"This study provides robust evidence showing a defect in the protein degradation pathway causes neurodegenerative disease," said Han-Xiang Deng, M.D., lead author of the paper and associate professor of neurology at the Feinberg School. "Abnormality in protein degradation has been suspected, but there was little direct evidence before this study." The other lead author is Wenjie Chen, senior research technologist in neurology.

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About 90 percent of ALS is sporadic, without any known cause, until this study. The remaining 10 percent is familial. To date, mutations in about 10 genes, several of which were discovered at Northwestern, including SOD1 and ALSIN, account for about 30 percent of classic familial ALS, noted Faisal Fecto, M.D., study co-author and a graduate student in neuroscience at Feinberg.


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Major ALS breakthrough [ Back to EurekAlert! ] Public release date: 21-Aug-2011
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Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University

Researchers discover common cause of all forms of ALS

CHICAGO --- The underlying disease process of amyotrophic lateral sclerosis (ALS and Lou Gehrig's disease), a fatal neurodegenerative disease that paralyzes its victims, has long eluded scientists and prevented development of effective therapies. Scientists weren't even sure all its forms actually converged into a common disease process.

But a new Northwestern Medicine study for the first time has identified a common cause of all forms of ALS.

The basis of the disorder is a broken down protein recycling system in the neurons of the spinal cord and the brain. Optimal functioning of the neurons relies on efficient recycling of the protein building blocks in the cells. In ALS, that recycling system is broken. The cell can't repair or maintain itself and becomes severely damaged.

The discovery by Northwestern University Feinberg School of Medicine researchers, published in the journal Nature, provides a common target for drug therapy and shows that all types of ALS are, indeed, tributaries, pouring into a common river of cellular incompetence.

"This opens up a whole new field for finding an effective treatment for ALS," said senior author Teepu Siddique, M.D., the Les Turner ALS Foundation/Herbert C. Wenske Professor of the Davee Department of Neurology and Clinical Neurosciences at Northwestern's Feinberg School and a neurologist at Northwestern Memorial Hospital. "We can now test for drugs that would regulate this protein pathway or optimize it, so it functions as it should in a normal state."

The discovery of the breakdown in protein recycling may also have a wider role in other neurodegenerative diseases, specifically the dementias. These include Alzheimer's disease and frontotemporal dementia as well as Parkinson's disease, all of which are characterized by aggregations of proteins, Siddique said. The removal of damaged or misfolded proteins is critical for optimal cell functioning, he noted.

This breakdown occurs in all three forms of ALS: hereditary, which is called familial; ALS that is not hereditary, called sporadic; and ALS that targets the brain, ALS/dementia.

In related research, Feinberg School researchers also discovered a new gene mutation present in familial ALS and ALS/dementia, linking these two forms of the disease.

Siddique has been searching for the causes and underlying mechanism of ALS for more than a quarter century. He said he was initially drawn to it because, "It was one of the most difficult problems in neurology and the most devastating, a disease without any treatment or known cause."

Siddique's efforts first showed in 1989 that molecular genetics techniques were applicable to ALS, then described the first ALS gene locus in 1991, which led to the discovery of SOD1 and engineering of the first genetic animal model for ALS.

ALS affects an estimated 350,000 people worldwide, including children and adults, with about 50 percent of people dying within three years of its onset. In the motor disease, people progressively lose muscle strength until they become paralyzed and can no longer move, speak, swallow and breathe. ALS/dementia targets the frontal and temporal lobes of the brain, affecting patients' judgment, the ability to understand language and to perform basic tasks like planning what to wear or organizing their day.

"These people in the prime of their lives and the peak of their productivity get this devastating illness that kills them," Siddique said. "The people who get ALS/dementia, an even more vicious disease, have a double whammy."

BROKEN DOWN RECYCLING SYSTEM

Feinberg School scientists found the cause of ALS by discovering a protein, ubiquilin2, whose critical job is to recycle damaged or misfolded proteins in motor and cortical neurons and shuttle them off to be reprocessed.

In people with ALS, Feinberg researchers found ubiquilin2 isn't doing its job. As a result, the damaged proteins and ubiquilin2 loiter and accumulate in the motor neurons in the spinal cord and cortical and hippocampal neurons in the brain. The protein accumulations resemble twisted skeins of yarn -- characteristic of ALS -- and cause the degeneration of the neurons.

Researchers found ubiquilin2 in these skein-like accumulations in the spinal cords of ALS cases and in the brains of ALS/dementia cases.

The scientists also discovered mutations in ubiquilin2 in patients with familial ALS and familial ALS/dementia. But the skein-like accumulations were present in people's brains and spinal cords in all forms of ALS and ALS/dementia, whether or not they had the gene mutation.

"This study provides robust evidence showing a defect in the protein degradation pathway causes neurodegenerative disease," said Han-Xiang Deng, M.D., lead author of the paper and associate professor of neurology at the Feinberg School. "Abnormality in protein degradation has been suspected, but there was little direct evidence before this study." The other lead author is Wenjie Chen, senior research technologist in neurology.

###

About 90 percent of ALS is sporadic, without any known cause, until this study. The remaining 10 percent is familial. To date, mutations in about 10 genes, several of which were discovered at Northwestern, including SOD1 and ALSIN, account for about 30 percent of classic familial ALS, noted Faisal Fecto, M.D., study co-author and a graduate student in neuroscience at Feinberg.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-08/nu-mab081711.php

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